Endocrine Abstracts

Introduction: The aim of the study was to assess the impact of obesity and birth weight (BW) at diagnosis of premature adrenarche (PA) in a large cohort of greek children.Methods/design: We assessed clinical and laboratory characteristics of 221 children (175 girls and 46 boys) at diagnosis of PA.Results: At diagnosis of PA 149 children (67.4%) had pubic hair (Tanner stage ≥2), 10 (4.5%) had axillary hair (Tanner stage &#8805...

Use of surrogate indices of insulin resistance depends on comparability of the relationship between glucose and insulin concentrations between different groups. It is unknown whether such surrogate estimates are equally applicable in different ethnic groups with marked differences in insulin sensitivity. We compared markers of insulin sensitivity and secretion in 78 (43 European, 19 Afro-Caribbean and 16 South Asian) normoglycaemic women of (median (lower-upper quartile)) 34.7...

To explore the correlation structure of individual components of the Metabolic Syndrome and identify combinations of correlated variables we used principal component analysis (PCA) in a multiethnic group of women with a history of GDM (pGDM) (185 European, 103 South Asian, 80 African–Caribbean), recruited at 20.0 (18.2–22.1) months (geometric mean (95% CI)) after pregnancy and 482 control women of similar ethnicities. BMI, W:H ratio, systolic and diastolic BP, f. glu...

Ectopic thyroid tissue, defined as thyroid tissue not located anterolaterally to the second and fourth tracheal cartages, is rare. In the majority of the cases it is located in the midline, between the foramen caecum and the proper location of the thyroid gland and most often it is found in the base of the tongue. We present a case of ectopic thyroid in the lower cervical area in a patient with a multinodular goiter. A 27-yr-old asymptomatic woman presented with a recent histo...

We investigated the relationship between gestational diabetes (GDM) and the metabolic syndrome in 368 (185 European (EUR), 103 South Asian (SA) and 80 Afro-Caribbean (AC)) women studied 20.0 (18.2-22.1) months (mean (95% CI)) following a GDM pregnancy and 482 normoglycaemic women (288 EUR, 99 SA, 95 AC) with no history of GDM. Estimates of beta-cell function (%B) and insulin sensitivity (%S) were derived using the HOMA method. Analysis was by multiple linear regression includi...